Arrhenius plots of fluoride- and guanine-nucleotide-stimulated adenylate cyclase activity were linear in adipocyte plasma membranes from lean and obese (ob/ob) mice. Arrhenius plots of isoprenaline-stimulated adenylate cyclase activity in hepatic plasma membranes biphasic in both groups. The results were biphasic in membranes from Jean mice but linear in membranes from obese mice. In contrast, Arrhenius plots of glucagon-stimulated adenylate cyclase activity in hepatic plasma membranes were biphasic in both groups. The results suggest that the coupling between the β-receptor and the regulatory unit of adenylate cyclase, which has been observed to be defective in adipocyte plasma membranes from obese mice, is influenced by a different lipid environment in membranes from obese animals.
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December 01 1984
Arrhenius plot characteristics of adipocyte-plasma-membrane adenylate cyclase activity in lean and genetically obese (ob/ob) mice
R. R. French;
R. R. French
1Department of Nutrition, School of Biochemical and Physiological Sciences, Southampton University, Southampton SO9 3TU, UK
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D. A. York
D. A. York
1Department of Nutrition, School of Biochemical and Physiological Sciences, Southampton University, Southampton SO9 3TU, UK
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Publisher: Portland Press Ltd
Received:
October 25 1984
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1984 The Biochemical Society
1984
Biosci Rep (1984) 4 (12): 1001–1008.
Article history
Received:
October 25 1984
Citation
R. R. French, D. A. York; Arrhenius plot characteristics of adipocyte-plasma-membrane adenylate cyclase activity in lean and genetically obese (ob/ob) mice. Biosci Rep 1 December 1984; 4 (12): 1001–1008. doi: https://doi.org/10.1007/BF01116692
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