In contrast to many differentiated hepatic functions developing after birth, very little is known about in vivo glucocorticoid influences on postnatal expression of fetal liver enzymes, such as GGT. This study showed that cortisol markedly induces liver GGT activity in unweaned rats, but has no effectafter weaning. Enzyme induction was dose- and time-dependent and occurred in parenchymal cells, progressing with time from zone 1 to zone 2 of the liver acinus. Zone-3 hepatocytes were unresponsive even after a 5-day treatment. Lag-times for GGT induction in zones I and 2 of the liver acinus were 1 to 2 days and 2 to 3 days, respectively. From this, a permissive cell change, determined by the hormone administration itself, seems required for the hepatocyte GGT induction by cortisol in pre-weaning rats.
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March 01 1984
Gamma-glutamyltranspeptidase induction by cortisol in liver parenchyma of unweaned rats
Roberto Tongiani;
Roberto Tongiani
1Istituto di Patologia Generale, Università degli Studi di Pisa, Via Roma 55, I-56100 Pisa, Italy
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Aldo Paolicchi;
Aldo Paolicchi
1Istituto di Patologia Generale, Università degli Studi di Pisa, Via Roma 55, I-56100 Pisa, Italy
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Elisabetta Chieli
Elisabetta Chieli
1Istituto di Patologia Generale, Università degli Studi di Pisa, Via Roma 55, I-56100 Pisa, Italy
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Publisher: Portland Press Ltd
Received:
January 13 1984
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1984 The Biochemical Society
1984
Biosci Rep (1984) 4 (3): 203–211.
Article history
Received:
January 13 1984
Citation
Roberto Tongiani, Aldo Paolicchi, Elisabetta Chieli; Gamma-glutamyltranspeptidase induction by cortisol in liver parenchyma of unweaned rats. Biosci Rep 1 March 1984; 4 (3): 203–211. doi: https://doi.org/10.1007/BF01119655
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