The thermogenic response to noradrenaline administration was investigated at 25° in two models of obese mice (genetic ob/ob obesity of the ‘QEC’ strain and monosodium-glutamate-induced obesity) and in their respective lean littermates. Subcutaneous injections of a low dose of noradrenaline (I00 μg/kg body wt.) eJevated metabolic rate by about 3096 in both obese models but not in their respective lean counterparts. In contrast, the increase in metabolic rate after injections of a high dose of noradrenaline (600 μg/kg body wt.) was of a similar magnitude in both lean and obese animals: metabolic rate was increased by 70–80%. These results indicate that the overall whole body thermogenic capacity is unimpaired at room temperature in this ‘QEC’ strain of ob/ob mice and in the hypothalamic damaged obese mice. Obesity in these models is therefore not associated with a reduced ability to respond to noradrenaline but could rather be due to a failure to release noradrenaline.
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April 01 1984
Unimpaired thermogenic response to noradrenaline in genetic (ob/ob) and hypothalamic (MSG) obese mice
A. G. Duloo;
A. G. Duloo
1Department of Nutrition, Queen Elizabeth College, University of London, Campden Hill Road, London W8 7AH, UK
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D. S. Miller
D. S. Miller
1Department of Nutrition, Queen Elizabeth College, University of London, Campden Hill Road, London W8 7AH, UK
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Publisher: Portland Press Ltd
Received:
March 07 1984
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1984 The Biochemical Society
1984
Biosci Rep (1984) 4 (4): 343–349.
Article history
Received:
March 07 1984
Citation
A. G. Duloo, D. S. Miller; Unimpaired thermogenic response to noradrenaline in genetic (ob/ob) and hypothalamic (MSG) obese mice. Biosci Rep 1 April 1984; 4 (4): 343–349. doi: https://doi.org/10.1007/BF01140498
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