Four days of fasting in the rat reduced brown-adipose-tissue (BAT) mass, mitochondrial protein, and tissue protein content. Specific binding of guanosine diposphate (GDP) to BAT mitochondria was depressed by 55% in 4d-fasted rats. Rats fasted for 3 d, and then refed a single carbohydrate meal (40 kJ), showed a significant increase in specific GDP-binding (27% above fasted) 24 h later, and a large increase in total binding. Specific activities of cytochrome oxidase and α-glycerophosphate dehydrogenase in BAT mitochondria were not significantly affected by fasting or refeeding. These results suggest that BAT may be partly responsible for the fall in metabolic rate associated with fasting and the delayed increase after carbo-hydrate refeeding. These effects may be due to changes in the mitochondrial proton-conductance pathway in brown fat.
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Research Article|
April 01 1984
Brown fat activity in fasted and refed rats
Nancy J. Rothwell;
Nancy J. Rothwell
1Department of Physiology, St. George's Hospital Medical School, Tooting, London SW17 0RE, UK
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M. Elizabeth Saville;
M. Elizabeth Saville
1Department of Physiology, St. George's Hospital Medical School, Tooting, London SW17 0RE, UK
*Department of Pharmaceutical Research, Hoffman-La Roche, 4002 Basel, Switzerland
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Michael J. Stock
Michael J. Stock
1Department of Physiology, St. George's Hospital Medical School, Tooting, London SW17 0RE, UK
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Publisher: Portland Press Ltd
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1984 The Biochemical Society
1984
Biosci Rep (1984) 4 (4): 351–357.
Citation
Nancy J. Rothwell, M. Elizabeth Saville, Michael J. Stock; Brown fat activity in fasted and refed rats. Biosci Rep 1 April 1984; 4 (4): 351–357. doi: https://doi.org/10.1007/BF01140499
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