Analyses of the rat mammary gland show that the increase in the milk-protein mRNAs during the development of lactation and the rapid disappearance of these sequences during involution are not accompanied by similar changes in the poly(A) content. During the development of lactation the casein mRNA is initially in great excess to the whey-protein mRNA and this differential expression of the genes for the two types of milk proteins is again observed during early involution. Since the amounts of poly(A) and of both milk-protein mRNAs are also similar to the amounts found in the gland during late pregnancy, these results indicate that during early involution the mammary gland has reverted to the pattern of mRNA metabolism that occurs during late pregnancy.
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April 01 1984
Milk-protein mRNAs and poly(A) in the involuting rat mammary gland return to the levels found during late pregnancy
Vasek A. Mezl;
Vasek A. Mezl
1Department of Biochemistry, Health Sciences Centre, University of Ottawa, Ottawa, Ont., Canada, K1H 8M5
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Susan Nadin-Davis
Susan Nadin-Davis
1Department of Biochemistry, Health Sciences Centre, University of Ottawa, Ottawa, Ont., Canada, K1H 8M5
*Division of Biological Sciences, National Research Council, Ottawa, Ontario, Canada, K1A OR6
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Publisher: Portland Press Ltd
Received:
March 16 1984
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1984 The Biochemical Society
1984
Biosci Rep (1984) 4 (4): 359–364.
Article history
Received:
March 16 1984
Citation
Vasek A. Mezl, Susan Nadin-Davis; Milk-protein mRNAs and poly(A) in the involuting rat mammary gland return to the levels found during late pregnancy. Biosci Rep 1 April 1984; 4 (4): 359–364. doi: https://doi.org/10.1007/BF01140500
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