The cellular onc- genes c-src and c-yes are expressed very differently during chicken embryonic development. The c-src mRNA and its translational product are detectable at high levels in brain extracts of chicken embryos and adult chickens) whereas muscle extracts show an age-dependent decrease in the amounts of c-src-specific mRNA and pp60c-src kinase activity. In contrast) the levels of c-yes mRNA in brain, heart, and muscle are relatively low in early embryonic stages and increase later on to values comparable to those found for liver) while in adult animals the pattern of c-yes expression is similar to that of the c-src gene. From the close correlation between the levels of pp60c-src its enzymatic activity, and its corresponding mRNA at a given stage of development and in given tissues) it appears that the expression of pp60c-src is primarily controlled at the level of transcription. It is suggested that because of the different patterns of expression) the two cellular oncogenes) c-src and c-yes) play different roles in cell proliferation during early embryonic stages as well as in ensuing differentiation processes.
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September 01 1984
Differential expression of the cellular oncogenes c-src and c-yes in embryonal and adult chicken tissues
Manfred Gessler;
Manfred Gessler
1Institut für Medizinische Virologie der Justus-Liebig-Universität Giessen, 107 Frankfurter Str., D-6300 Giessen, Germany
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Angelika Barnekow
Angelika Barnekow
1Institut für Medizinische Virologie der Justus-Liebig-Universität Giessen, 107 Frankfurter Str., D-6300 Giessen, Germany
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Publisher: Portland Press Ltd
Received:
August 03 1984
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1984 The Biochemical Society
1984
Biosci Rep (1984) 4 (9): 757–770.
Article history
Received:
August 03 1984
Citation
Manfred Gessler, Angelika Barnekow; Differential expression of the cellular oncogenes c-src and c-yes in embryonal and adult chicken tissues. Biosci Rep 1 September 1984; 4 (9): 757–770. doi: https://doi.org/10.1007/BF01128817
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