Isolated mouse pancreatic islets were infected in vitro with two strains of Coxsackie B4 virus – a tissue culture – adapted strain and a mouse pancreas-adapted strain. Within 48 h of infection changes had occurred in the biochemical activities of islets infected with the mouse pancreas-adapted strain of virus. Basal insulin release was increased two-fold in these islets, while glucose-induced insulin secretion remained unchanged. Insulin biosynthesis was greatly reduced at a sti, mulatory concentration of glucose (20 raM), thus leading to a reduced insulin content in these islets. These effects are of importance because they demonstrate that certain strains of Coxsackie B4 virus, like encephalo-myocarditis virus, may selectively alter B-cell function in vitro.
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Research Article|
January 01 1985
Biochemical changes induced by Coxsackie B4 virus in short-term culture of mouse pancreatic islets
T. M. Szopa;
T. M. Szopa
1Department of Biochemistry, The London Hospital Medical College, London, England
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D. R. Gamble;
D. R. Gamble
2Public Health Laboratory, West Park Hospital, Epsom, Surrey, England
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K. W. Taylor
K. W. Taylor
1Department of Biochemistry, The London Hospital Medical College, London, England
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Publisher: Portland Press Ltd
Received:
December 10 1984
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1985 The Biochemical Society
1985
Biosci Rep (1985) 5 (1): 63–69.
Article history
Received:
December 10 1984
Citation
T. M. Szopa, D. R. Gamble, K. W. Taylor; Biochemical changes induced by Coxsackie B4 virus in short-term culture of mouse pancreatic islets. Biosci Rep 1 January 1985; 5 (1): 63–69. doi: https://doi.org/10.1007/BF01117442
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