The role of Class I major histocompatibility (MHC) antigens in the induction of specific suppression of graft rejection has been investigated. Two experimental transplantation models have been used ’ fully vascularized heterotopic Cardiac altografts in the mouse and fully vascularized orthotopic renal allografts in the rat. Preparations of ceils expressing Class I MHC antigens, for example highly purified preparations of rat erythrocytes or platelets or mouse L cells (H2k) transfected with the D locus Class I gene of the b haplotype, LDb-1 cells, were used to pretreat recipients prior to transplantation, The function of the allograft was monitored in order to assess any beneficial effects induced by Class I MHC antigens. The results obtained implicate Class I MHC as important in the induction of specific immunosuppression of vascularized allograft rejection.
Skip Nav Destination
Article navigation
Research Article|
January 01 1985
Antigen-induced suppression: The role of Class I major histocompatibility antigens
Kathryn J. Wood;
Kathryn J. Wood
1Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
Search for other works by this author on:
Peter J. Morris
Peter J. Morris
1Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
August 09 1985
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1985 The Biochemical Society
1985
Biosci Rep (1985) 5 (10-11): 1007–1014.
Article history
Received:
August 09 1985
Citation
Kathryn J. Wood, Peter J. Morris; Antigen-induced suppression: The role of Class I major histocompatibility antigens. Biosci Rep 1 January 1985; 5 (10-11): 1007–1014. doi: https://doi.org/10.1007/BF01119913
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Cited By
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |