This paper presents a short review of our contribution to the knowledge of the structure and function of human Clr, the activation unit of C1, the first component of the classical pathway of complement. On the basis of the domain structure of Clr, a model accounting for its autolytic activation mechanism is proposed. We suggest that this represents the basic mechanism of C1 function.
C1r serine proteinase of human complement: A case of intramolecular autolytic activation
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Gérard J. Arlaud, Maurice G. Colomb, Christian L. Villiers; C1r serine proteinase of human complement: A case of intramolecular autolytic activation. Biosci Rep 1 January 1985; 5 (10-11): 831–837. doi: https://doi.org/10.1007/BF01119894
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