The activity of topoisomerase I in nuclear extracts increased about three-fold 5 min after γ-irradiation (840–2500 rads) of human peripheral blood lymphocytes or cultured lymphoblastoid cells. The change may reflect modification of the enzyme by nuclear ADP-ribosyl transferase, which is known to be activated by DNA breaks.
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© 1985 The Biochemical Society
1985
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