Male rats were treated with triiodothyronine in the drinking water for 12 days. In vitro rates of isoprenaline stimulated lipolysis were significantly greater in brown but not white adipose tissue. Rates of [14C]glucose incorporation into triacylglycerols were significantly reduced in BAT (brown adipose tissue) and WAT (white adipose tissue) under basal and isoprenaline stimulated conditions, in a second experiment, hyperthyroid animals showed impaired weight gain, despite increased food intake during t9 days' treatment. Energy expenditure on days 5 and 12, and BAT core temperature differences (TBAT – TCORE) on day 19, were significantly greater than in control animals. Epididymal white fat pad weight was reduced and interscapular brown fat pad weight increased by triiodothyronine treatment.
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Research Article|
February 01 1985
Thermogenic and metabolic consequences of thyroid hormone treatment in brown and white adipose tissue
Christine M. Williams;
Christine M. Williams
1Department of Biological Sciences, North East Surrey College of Technology, Reigate Road, Ewell, Surrey, UK
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Rodney Ellis
Rodney Ellis
2Beecham Pharmaceuticals Research Division, Biosciences Research Centre, Great Burgh, Epsom, Surrey, UK
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Publisher: Portland Press Ltd
Received:
February 22 1985
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1985 The Biochemical Society
1985
Biosci Rep (1985) 5 (2): 175–184.
Article history
Received:
February 22 1985
Citation
Christine M. Williams, Rodney Ellis; Thermogenic and metabolic consequences of thyroid hormone treatment in brown and white adipose tissue. Biosci Rep 1 February 1985; 5 (2): 175–184. doi: https://doi.org/10.1007/BF01117064
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