Renal failure is associated with peripheral insulin resistance and consequent carbohydrate intolerance. This report investigates carbohydrate metabolism in vitro in epitrochlearis and hemidiaphragm muscles taken from acutely uraemic and sham-operated rats. Muscles from acutely uraemic rats (compared to those from sham-operated rats) incubated with 5 mM glucose showed increased rates of basal and insulin-stimulated glycolysis and glycogen turnover, but pyruvate dehydro-genase and tricarboxylic acid – cycle flux was not increased in uraemia. Glycolysis (but not glycogen turnover) in muscles from acutely uraemic rats tended to show decreased responsiveness to stimulation by insulin. It is concluded that acute uraemia is associ-ated with a defect(s) in muscle that produces intrinsic insulin resistance and results in diversion of glucose (both in basal and insulin-stimulated states) from glycogen synthesis into glycolysis.
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May 01 1985
Impaired muscle glucose metabolism in acute renal failure
T. Norman Palmer;
T. Norman Palmer
1Department of Biochemistry, Charing Cross and Westminister Medical School, Fulham Palace Road, London W6 8RF, UK
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Margaret A. Caldecourt;
Margaret A. Caldecourt
1Department of Biochemistry, Charing Cross and Westminister Medical School, Fulham Palace Road, London W6 8RF, UK
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Savita Gossain;
Savita Gossain
1Department of Biochemistry, Charing Cross and Westminister Medical School, Fulham Palace Road, London W6 8RF, UK
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Sheila Mangat;
Sheila Mangat
1Department of Biochemistry, Charing Cross and Westminister Medical School, Fulham Palace Road, London W6 8RF, UK
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C. Sugden
C. Sugden
1Department of Chemical Pathology, London Hospital Medical College, Turner Street, London E1 2AD, UK
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Publisher: Portland Press Ltd
Received:
April 04 1985
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1985 The Biochemical Society
1985
Biosci Rep (1985) 5 (5): 433–438.
Article history
Received:
April 04 1985
Citation
T. Norman Palmer, Margaret A. Caldecourt, Savita Gossain, Sheila Mangat, C. Sugden; Impaired muscle glucose metabolism in acute renal failure. Biosci Rep 1 May 1985; 5 (5): 433–438. doi: https://doi.org/10.1007/BF01116561
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