The effect of T3 (triiodothyronine) on the induction of tubulin in hypothyroid developing rat brain has been examined using organ cultures of brains from late fetal, neonatal and postnatalrats. The neonatal brain displayed maximum sensitivity to T3. Hypothyroidism resulted in a 26% decline in the level of tubulin in the neonatal brain as opposed to a 5–15% decline in the fetal or postnatal brain. Exposure of the hypothyroi d neonatal brain to T3 for 2 h in culture led to a 61% rise in the level of tubulin in contrast to a 41% increase seen in the case of normal brain. Total protein synthesis was not significantly affected. The preferential decline of tubulin in the neonatal hypothyroid brain, its enhanced sensitivity to T3 compared to normal brain, and the coincidence of the period of sensitivity to that of brain maturation indicate that the regulation of the level of tubulin by T3 in the developing brain is a natural ontogenic phenomenon.
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August 01 1985
Regulation of tubulin by triiodothyronine in hypothyroid rat brain
Anjana Mazumder;
Anjana Mazumder
1Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Road, Calcutta 700 032, India
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Kamal Das;
Kamal Das
1Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Road, Calcutta 700 032, India
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Pranab K. Sarkar
Pranab K. Sarkar
1Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Road, Calcutta 700 032, India
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Publisher: Portland Press Ltd
Received:
July 02 1985
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1985 The Biochemical Society
1985
Biosci Rep (1985) 5 (8): 643–648.
Article history
Received:
July 02 1985
Citation
Anjana Mazumder, Kamal Das, Pranab K. Sarkar; Regulation of tubulin by triiodothyronine in hypothyroid rat brain. Biosci Rep 1 August 1985; 5 (8): 643–648. doi: https://doi.org/10.1007/BF01116995
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