The expression of C3b receptors (CR1) on erythrocytes of gay men at various levels of risk for AIDS was studied. Fourty-nine heterosexual male controls had a mean (X) ± standard deviation of 516 ± 136 CR1 per erythrocyte (CR1-3); 17 asymptomatic gay men had X = 423 ± 156, 16 gay men with one AIDS-related complex (ARC) symptom or sign had X = 342 ± 154, 9 patients with ARC had X = 252 ± 76, and 14 gay men with AIDS had X = 173 ± 76 CR1-E. The patients with ARC and AIDS had a highly significant decrease in CR1-E when compared with normal individuals (p = <0.001) and studies of families of 4 AIDS patients suggest that this defect is acquired.
Deficiency of erythrocyte C3b receptor (CR1) in AIDS and AIDS-related syndromes
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Francisco A. Tausk, J. Allen McCutchan, Robert D. Schreiber, Phyllis Spechko, Irma Gigli; Deficiency of erythrocyte C3b receptor (CR1) in AIDS and AIDS-related syndromes. Biosci Rep 1 January 1986; 6 (1): 81–86. doi: https://doi.org/10.1007/BF01145182
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