Sulphate efflux from human placental microvillus membrane vesicles was inhibited by external DIDS (KI≅10−6 M). This inhibition was partially reversed on addition of the translocated substrates sulphate or selenate to the external medium: selenite which is not translocated does not protect against DIDS inhibition. These findings show that the mechanism responsible for sulphate efflux can be modified by substrate in the external medium.

This content is only available as a PDF.
You do not currently have access to this content.