Herpes simplex virus Type 2 causes a severe repression of host cell biosynthesis at a number of levels. We show that despite this, non-viral cDNA clones derived from cellular RNA species which accumulate to high levels after infection can be isolated using differential screening techniques. By using nuclear run-off assays, we have shown that this RNA accumulation is mediated by transcriptional induction of the corresponding cellular genes.
Transcriptional induction of cellular gene expression during lytic infection with herpes simplex virus
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L. M. Kemp, P. M. Brickell, N. B. La Thangue, D. S. Latchman; Transcriptional induction of cellular gene expression during lytic infection with herpes simplex virus. Biosci Rep 1 November 1986; 6 (11): 945–951. doi: https://doi.org/10.1007/BF01114970
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