The sodium contents of β-cell-rich pancreatic islets from ob/ob-mice were measured with an integrating flame photometer. After washing to an apparent steady state with different types of ice-cold media, islets incubated in the absence of glucose contained 79–108 mmol sodium kg−1 dry weight. Exposure to glucose resulted in 25 % reduction of the islet content of sodium. This effect became manifest in the presence of 5 mM glucose, there being no additional reduction with a further increase of glucose to 20 mM. Depression of Na+ activity may partially explain why glucose, under certain conditions, can lower cytoplasmic Ca2+ and even inhibit insulin release.
Rapid Communication| November 01 1986
Glucose-induced reduction of the sodium content in β-cell-rich pancreatic islets
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Nils Wesslén, Peter Bergsten, Bo Hellman; Glucose-induced reduction of the sodium content in β-cell-rich pancreatic islets. Biosci Rep 1 November 1986; 6 (11): 967–972. doi: https://doi.org/10.1007/BF01114973
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