Monolayer culture of bovine parathyroid cells for 24 hours resulted in a right-shift of the dose-effect relationships for Ca2+-inhibition of parathyroid hormone (PTH) release and the dependence of the cytoplasmic Ca2+ concentration (Ca2+) on extracellular Ca2+ as well as in a less suppressible hormone release. After 4 days of culture, hormone secretion was almost non-suppressible and Cai2+ increased poorly in response to a rise in extracelluiar Ca2+. Ionomycin, a Ca2+ ionophore, raised Cai2+, but there was only a small inhibition of PTH release and the correlation between Cai2+ and secretion was weak. A deteriorated Cai2+ regulation and a decreased inhibitory action of cytoplasmic Ca2+ on PTH release were also found in ceils from human parathyroid adenomas. Functional dedifferentiation of the parathyroid cell thus results from both defective regulation and action of cytoplasmic Ca2+.
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December 01 1986
Functional dedifferentiation of parathyroid cells results both from a defective regulation and action of cytoplasmic Ca2+
Peter Nygren
Peter Nygren
1Department of Medical Cell Biology, University of Uppsala, Box 571, S-751 23 Uppsala, Sweden
2Department of Surgery, University of Uppsala, Box 571, S-751 23 Uppsala, Sweden
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Publisher: Portland Press Ltd
Received:
January 21 1987
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1986 Plenum Publishing Corporation
1986
Biosci Rep (1986) 6 (12): 1057–1063.
Article history
Received:
January 21 1987
Citation
Peter Nygren; Functional dedifferentiation of parathyroid cells results both from a defective regulation and action of cytoplasmic Ca2+. Biosci Rep 1 December 1986; 6 (12): 1057–1063. doi: https://doi.org/10.1007/BF01141027
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