Present evidence is highly suggestive of a stepwise mechanism with a common initial step of HCO3− activation, for all enzymes that use HCO3− rather than CO2 as the substrate. This activated form of HCO3− appears to be the carbonic-phosphoric anhydride, although this has only been proved rigorously with carbamoyl phosphate synthetase. Further studies using isotope scrambling and other techniques will be necessary to establish conclusively that this is the case with the other enzymes.
Review Article| April 01 1986
Enzymatic HCO3− fixation: A common mechanism for all enzymes involved?
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Vicente Rubio; Enzymatic HCO3− fixation: A common mechanism for all enzymes involved?. Biosci Rep 1 April 1986; 6 (4): 335–347. doi: https://doi.org/10.1007/BF01116420
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