Partial (60%) resection of rat small bowel was performed in order to obtain a model of intestinal mucosal hyperplasia for studying specific insulin binding. The affinity, but not the binding capacity, of insulin receptors in the adaptive mucosa decreased three and seven days following enterectomy. This modification took place only in crypt cells but not in mature villous cells. Since plasma insulin levels were not altered by the surgical manipulation, the observed decrease of insulin binding could not be related to regulation by insulin concentration. These results do not support a trophic role of insulin on intestinal mucosa and appear to be more a consequence of the hyperactive status of proliferation and differentiation at the mucosat level.
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May 01 1986
Insulin binding to rat intestinal epithelial cells following partial small-bowel resection
Maria-Dolores Fernandez-Moreno;
Maria-Dolores Fernandez-Moreno
1Departamento de Bioquimica y Biologia Molecular, Universidad de Alcalá de Henares, Madrid, Spain
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Eduardo Arilla;
Eduardo Arilla
1Departamento de Bioquimica y Biologia Molecular, Universidad de Alcalá de Henares, Madrid, Spain
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Juan-Carlos Prieto
Juan-Carlos Prieto
1Departamento de Bioquimica y Biologia Molecular, Universidad de Alcalá de Henares, Madrid, Spain
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Publisher: Portland Press Ltd
Received:
March 12 1986
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1986 Plenum Publishing Corporation
1986
Biosci Rep (1986) 6 (5): 445–450.
Article history
Received:
March 12 1986
Citation
Maria-Dolores Fernandez-Moreno, Eduardo Arilla, Juan-Carlos Prieto; Insulin binding to rat intestinal epithelial cells following partial small-bowel resection. Biosci Rep 1 May 1986; 6 (5): 445–450. doi: https://doi.org/10.1007/BF01116135
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