The involvement of phosphoinositide hydrolysis in the action of oxytocin and vasopressin on the uterus was investigated in gestational myometrium and decidua cells by measuring the production of inositol phosphates. Both peptides stimulated a dose related increase in all three inositol phosphates in myometrium. This may be related to the control of sarcoplasmic Ca++ levels in the myometrium. Oxytocin and vasopressin also stimulated inositol 1-phosphate (IP) production in decidua cells. The hydrolysis of phosphatidylinositol by decidua homogenates exhibited a precursor-product relationship for diacylglycerol and arachidonic acid accumulation. Hence both peptides may mobilise free arachidonic acid, for prostaglandin biosynthesis, from decidua cell phosphoinositides by the sequential action of phospholipase C and diacylglycerol lipase.
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July 01 1986
Oxytocin and vasopressin stimulate inositol phosphate production in human gestational myometrium and decidua cells
Michael P. Schrey;
Michael P. Schrey
1Department of Chemical Pathology, St Mary's Hospital Medical School, University of London, London W2 1PG
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Alison M. Read;
Alison M. Read
1Department of Chemical Pathology, St Mary's Hospital Medical School, University of London, London W2 1PG
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Philip J. Steer
Philip J. Steer
2Department of Obstetrics and Gynaecology, St Mary's Hospital Medical School, University of London, London W2 1PG
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Publisher: Portland Press Ltd
Received:
July 02 1986
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1986 Plenum Publishing Corporation
1986
Biosci Rep (1986) 6 (7): 613–619.
Article history
Received:
July 02 1986
Citation
Michael P. Schrey, Alison M. Read, Philip J. Steer; Oxytocin and vasopressin stimulate inositol phosphate production in human gestational myometrium and decidua cells. Biosci Rep 1 July 1986; 6 (7): 613–619. doi: https://doi.org/10.1007/BF01114755
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