Tropomyosin polymerization is inhibited by DNAse I, an endonuclease which also interacts with G-actin. A 1:4 molar ratio of DNAse I to adult chicken pectoralis muscle tropomyosin almost completely prevents the increased viscosity of tropomyosin under polymerizing ionic conditions. While G-actin binding to DNAse I inhibits the DNAse I hydrolysis of DNA, tropomyosin does not affect this enzymatic activity. G-actin-DNAse I interaction is also not altered by tropomyosin.
Rapid Communication| August 01 1986
Inhibition of muscle tropomyosin polymerization by DNAse I
Michael R. Payne;
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Michael R. Payne, Suzanne E. Rudnick; Inhibition of muscle tropomyosin polymerization by DNAse I. Biosci Rep 1 August 1986; 6 (8): 721–726. doi: https://doi.org/10.1007/BF01116539
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