In this study, the nucleotide sequences of the 3′ untranslated regions (UTR) of the mouse and human c-fos genes, and the rat and human β-actin genes were examined. It is shown (i) that the 3′ UTR of c-fos is highly conserved between mouse and man, (ii) that multiple copies of a 12 bp element occur, in clusters, in the 3′ UTR both of c-fos and of β-actin. This conserved 12 bp element is analogous to the putative repressor binding site previously identified (Renan, Bioscience Reports,5 (1985), 739–753). These findings provide additional support for the proposal that regulatory signals are located in the 3′ UTR's of certain genes.
Rapid Communication| September 01 1986
Conserved elements in the 3′ untranslated regions of c-fos and actin mRNAs
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Michael J. Renan; Conserved elements in the 3′ untranslated regions of c-fos and actin mRNAs. Biosci Rep 1 September 1986; 6 (9): 819–825. doi: https://doi.org/10.1007/BF01117105
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