In this study, the nucleotide sequences of the 3′ untranslated regions (UTR) of the mouse and human c-fos genes, and the rat and human β-actin genes were examined. It is shown (i) that the 3′ UTR of c-fos is highly conserved between mouse and man, (ii) that multiple copies of a 12 bp element occur, in clusters, in the 3′ UTR both of c-fos and of β-actin. This conserved 12 bp element is analogous to the putative repressor binding site previously identified (Renan, Bioscience Reports,5 (1985), 739–753). These findings provide additional support for the proposal that regulatory signals are located in the 3′ UTR's of certain genes.

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