Chronic dietary administration of the oral hypoglycaemic ciglitazone (3 g/day for 14–28 days) to lean, non-diabetic CD1 mice resulted in increased brown adipose tissue mitochondrial GDP binding and a marked increase in the thermic effect of the beta-adrenoceptor agonist BRL 26830A. However, ciglitazone was not itself thermogenic after an acute dose, nor did it raise resting metabolic rate during chronic dietary dosing.
Keywords:
ciglitazone,
thermogenesis,
brown adipose tissue,
GDP binding,
mice,
BRL 26830A,
beta agonist,
metabolic rate
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© 1987 Plenum Publishing Corporation
1987
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