Chronic dietary administration of the oral hypoglycaemic ciglitazone (3 g/day for 14–28 days) to lean, non-diabetic CD1 mice resulted in increased brown adipose tissue mitochondrial GDP binding and a marked increase in the thermic effect of the beta-adrenoceptor agonist BRL 26830A. However, ciglitazone was not itself thermogenic after an acute dose, nor did it raise resting metabolic rate during chronic dietary dosing.

This content is only available as a PDF.
You do not currently have access to this content.