Human adipocytes from patients with chronic endogenous hypercortisolism (Cushing's syndrome) showed a statistically significant decrease in insulin binding at low unlabelled-insulin concentrations but no change in receptor numbers (Cushing's 180,000±48,000 (3) receptors/cell and controls 189,000±30,000 (7)) together with a fourfold decrease in apparent receptor affinity (ED50: Cushing's 2.25×10−9 M and controls 0.57×10−9 M) and a decreased sensitivity to the antilipolytic effect of insulin. These events could represent the final situation of a chronic and endogenous regulation by high levels of cortisol of insulin receptors in human adipose tissue.
Decreased insulin binding and antilipolytic response in adipocytes from patients with Cushing's syndrome
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C. Calle, M. C. Carranza, M. A. Simón, A. Torres, P. Mayor; Decreased insulin binding and antilipolytic response in adipocytes from patients with Cushing's syndrome. Biosci Rep 1 September 1987; 7 (9): 713–719. doi: https://doi.org/10.1007/BF01116864
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