Cell killing by human immunodeficiency virus (HIV) is thought to contribute to many of the defects of the acquired immunodeficiency syndrome (AIDS). Two types of cytopathology are observed in HIV-infected cultured cells: cell-cell fusion and killing of single cells. Both killing processes appear to involve cell surface effects of HIV. A model is proposed for the HIV-mediated cell surface processes which could result in cell-cell fusion and single cell killing. The purpose of this model is to define the potential roles of individual viral envelope and cell surface molecules in cell killing processes and to identify alternative routes to the establishment of persistently-infected cells. Elucidation of HIV-induced cell surface effects may provide the basis for a rational approach to the design of antiviral agents which are selective for HIV-infected cells.
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February 01 1988
Cell surface effects of human immunodeficiency virus
Robert F. Garry;
Robert F. Garry
1Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, Louisiana
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A. Arthur Gottlieb;
A. Arthur Gottlieb
1Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, Louisiana
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Kenneth P. Zuckerman;
Kenneth P. Zuckerman
1Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, Louisiana
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John R. Pace;
John R. Pace
1Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, Louisiana
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Thomas W. Frank;
Thomas W. Frank
1Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, Louisiana
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Denise A. Bostick
Denise A. Bostick
1Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, Louisiana
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Publisher: Portland Press Ltd
Received:
January 05 1988
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1988 Plenum Publishing Corporation
1988
Biosci Rep (1988) 8 (1): 35–48.
Article history
Received:
January 05 1988
Citation
Robert F. Garry, A. Arthur Gottlieb, Kenneth P. Zuckerman, John R. Pace, Thomas W. Frank, Denise A. Bostick; Cell surface effects of human immunodeficiency virus. Biosci Rep 1 February 1988; 8 (1): 35–48. doi: https://doi.org/10.1007/BF01128970
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