A number of substances affect the activity of protein kinase C. Among uncharged and zwitterionic compounds, those which activate protein kinase C also lower the bilayer to hexagonal phase transition temperature of dielaidoylphosphatidylethanolamine while substances which inhibit protein kinase C raise this transition temperature. Using this criteria, we have identified 3β-chloro-5-cholestene, 5β-cholan-24-ol and eicosane as new protein kinase C activators and have shown that Z-Ser-Leu-NH2, Z-Gly-Leu-NH2, Z-Tyr-Leu-NH2, cyclosporin A and cholestan-3β, 5α, 6β-triol are protein kinase C inhibitors.
The relationship between the bilayer to hexagonal phase transition temperature in membranes and protein kinase C activity
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Richard M. Epand, Alan R. Stafford, James J. Cheetham, Remo Bottega, Eric H. Ball; The relationship between the bilayer to hexagonal phase transition temperature in membranes and protein kinase C activity. Biosci Rep 1 February 1988; 8 (1): 49–54. doi: https://doi.org/10.1007/BF01128971
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