The cytoplasmic pH undergoes a biphasic change when neutrophils are activated. The role of Ca2+ in initiating these changes was investigated. No correlation was found between the increased cytosolic [Ca2+] and the stimulation of the Na+/H+ antiport. Similarly, the cytoplasmic acidification elicited by activation in Na+-free media was found to be unrelated to [Ca2+]. Reversal of Na+/H+ exchange was also ruled out as the source of the acidification. Data using a variety of soluble activators indicate that metabolic acid generation is largely responsible for the observed drop in cytoplasmic pH.
Rapid Communication| February 01 1988
Cytosolic calcium, oxygen consumption and the intracellular pH of stimulated neutrophils
Patricia E. Nasmith;
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Patricia E. Nasmith, Sergio Grinstein; Cytosolic calcium, oxygen consumption and the intracellular pH of stimulated neutrophils. Biosci Rep 1 February 1988; 8 (1): 65–76. doi: https://doi.org/10.1007/BF01128973
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