The incorporation of mevalonate into nonsaponifiable lipids by chick liver in vivo strongly increased between 1–18 days after hatching. Cholesterol feeding (2%) inhibited this. Synthesis of cholesterol was strongly inhibited, whereas the intermediates isolated by TLC accumulated. Most of the polar nonsaponifiable lipids that accumulated in liver 90 minutes after mevalonate administration to 18-day-old cholesterol-fed chicks were identified as lanosterol derivative. 3-Hydroxy-3-methylglutaryl-CoA reductase activity, as well as acetate and mevalonate incorporation into nonsaponifiable lipids, was inhibited by the presence of these compounds. To our knowledge, this is the first report of such inhibition; this confirms the physiological function of polar steroids in the regulation of cholesterogenesis in vivo.
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April 01 1988
Regulation of hepatic cholesterogenesis by polar steroids accumulated after cholesterol feeding
Juan A. Aguilera;
Juan A. Aguilera
1Department of Biochemistry and Molecular Biology, University of Granada, 18071, Granada, Spain
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Virginia García-Molina;
Virginia García-Molina
1Department of Biochemistry and Molecular Biology, University of Granada, 18071, Granada, Spain
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Victor Arce;
Victor Arce
1Department of Biochemistry and Molecular Biology, University of Granada, 18071, Granada, Spain
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Eduardo García-Peregrín
Eduardo García-Peregrín
1Department of Biochemistry and Molecular Biology, University of Granada, 18071, Granada, Spain
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Publisher: Portland Press Ltd
Received:
February 15 1988
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1988 Plenum Publishing Corporation
1988
Biosci Rep (1988) 8 (2): 155–162.
Article history
Received:
February 15 1988
Citation
Juan A. Aguilera, Virginia García-Molina, Victor Arce, Eduardo García-Peregrín; Regulation of hepatic cholesterogenesis by polar steroids accumulated after cholesterol feeding. Biosci Rep 1 April 1988; 8 (2): 155–162. doi: https://doi.org/10.1007/BF01116460
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