Chick embryo sternal chondrocytes from the caudal and cephalic regions were cultured within type I collagen gels and type I collagen/proteoglycan aggregate composite gels in normal serum. Caudal region chondrocytes were also cultured within type I collagen gels in the presence of fibronectindepleted serum. There was a marked stimulation of type X collagen synthesis by the caudal region chondrocytes after 9 days in the presence of fibronectin-depleted serum and after 14 days in the presence of proteoglycan aggregate. These results provide evidence for the ability of chondrocytes from a zone of permanent cartilage to synthesise type X collagen and for the involvement of extracellular matrix components in the control of type X collagen gene expression.
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April 01 1988
Cartilage proteoglycan aggregate and fibronectin can modulate the expression of type X collagen by embryonic chick chondrocytes cultured in collagen gels
J. Terrig Thomas;
J. Terrig Thomas
1Department of Biochemistry & Molecular Biology, School of Biological Sciences, Stopford Building, University of Manchester, Oxford Road, Manchester, M13 9PT
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Michael E. Grant
Michael E. Grant
1Department of Biochemistry & Molecular Biology, School of Biological Sciences, Stopford Building, University of Manchester, Oxford Road, Manchester, M13 9PT
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Publisher: Portland Press Ltd
Received:
February 15 1988
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1988 Plenum Publishing Corporation
1988
Biosci Rep (1988) 8 (2): 163–171.
Article history
Received:
February 15 1988
Citation
J. Terrig Thomas, Michael E. Grant; Cartilage proteoglycan aggregate and fibronectin can modulate the expression of type X collagen by embryonic chick chondrocytes cultured in collagen gels. Biosci Rep 1 April 1988; 8 (2): 163–171. doi: https://doi.org/10.1007/BF01116461
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