The involvement of intracellular cytoskeletal elements in the translocation of the dexamethasone-receptor complex from the cytoplasm to the nucleus was studied using the cytoskeleton-disrupting agents colcemide, colchicine and cytochalasin B. These compounds did not affect the translocation of the hormone-receptor complex. We conclude that microfilaments and microtubules do not play a role in the translocation of the glucocorticoid hormone-receptor complex from the cytoplasm to the nucleus.

Keywords:
glucocorticoid hormone-receptor, translocation, colcemide, colchicine, cytochalasin B, cytoskeleton
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© 1988 Plenum Publishing Corporation
1988
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