Recent reports on the interaction of cardiotoxin and melittin with phospholipid model membranes are reviewed and analyzed. These types of peptide toxins are able to modulate lipid surface curvature and polymorphism in a highly lipid-specific way. It is demonstrated that the remarkable variety of effects of melittin on the organization of different membrane phospholipids can be understood in a relatively simple model, based on the shape-structure concept of lipid polymorphism and taking into account the position of the peptide molecule with respect to the lipids. Based on the strong preference of the peptides for negatively charged lipids and the structural consequences thereof, and on preliminary studies of signal peptide-lipid interaction, a role of inverted or concave lipid structures in the process of protein translocation across membranes is suggested.
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Review Article|
August 01 1988
Modulation of membrane surface curvature by peptide-lipid interactions
A. M. Batenburg;
A. M. Batenburg
1Department of Biochemistry and Institute of Molecular Biology and Medical Biotechnology, University of Utrecht, Padualaan 8, 3584 CH, Utrecht, The Netherlands
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B. de Kruijff
B. de Kruijff
1Department of Biochemistry and Institute of Molecular Biology and Medical Biotechnology, University of Utrecht, Padualaan 8, 3584 CH, Utrecht, The Netherlands
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Publisher: Portland Press Ltd
Received:
March 28 1988
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1988 Plenum Publishing Corporation
1988
Biosci Rep (1988) 8 (4): 299–307.
Article history
Received:
March 28 1988
Citation
A. M. Batenburg, B. de Kruijff; Modulation of membrane surface curvature by peptide-lipid interactions. Biosci Rep 1 August 1988; 8 (4): 299–307. doi: https://doi.org/10.1007/BF01115220
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