Recent studies have shown that the H-2K and H-2D transplantation antigens are expressed differentially in different tissues of mouse. Our previous investigations also established that in thioglycolate-stimulated peritoneal macrophages the H-2Dk antigen exists in distinct cell surface and intracellular forms. These two forms are glycosylated differently. In this report, we have found that (1) H-2Dk antigen is phosphorylated whereas H-2Kk antigen is not, and (2) only the cell surface form of H-2Dk antigen is phosphorylated in thioglycolate-stimulated macrophages derived from C3H/Heha mice. This differential phosphorylation of H-2 antigens will provide a model system for further studies on the molecular mechanism and function of phosphrrylation of H-2 antigens.
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August 01 1988
Differential phosphorylation of murine class I major histocompatibility antigens
Wanjin Hong;
Wanjin Hong
1Department of Biological Science, State University of New York at Buffalo, Buffalo, New York 14260, USA
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Anh Van Le;
Anh Van Le
1Department of Biological Science, State University of New York at Buffalo, Buffalo, New York 14260, USA
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Darrell Doyle
Darrell Doyle
1Department of Biological Science, State University of New York at Buffalo, Buffalo, New York 14260, USA
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Publisher: Portland Press Ltd
Received:
April 04 1988
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1988 Plenum Publishing Corporation
1988
Biosci Rep (1988) 8 (4): 353–358.
Article history
Received:
April 04 1988
Citation
Wanjin Hong, Anh Van Le, Darrell Doyle; Differential phosphorylation of murine class I major histocompatibility antigens. Biosci Rep 1 August 1988; 8 (4): 353–358. doi: https://doi.org/10.1007/BF01115226
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