Using probes specific for several oncogenes/proto-oncogenes we have performed gel blot hybridization analyses of genomic DNA isolated from the sea urchin Strongylocentrotus droebachiensis. Probes prepared from v-erbB, v-myc, c-myb and v-fps were found to hybridize with discrete fragments of HindIII digested genomic DNA. In contrast, probes prepared from v-abl, v-fos, v-sis, v-src, and v-mos either hybridized with multiple fragments, indicating non-specific binding, or failed to hybridize at all above background levels. These results clearly demonstrate the presence of proto-oncogene homologous sequences in the sea urchin genome.
Rapid Communication| October 01 1988
Proto-oncogene homologous sequences in the sea urchin genome
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David Mifflin, John J. Robinson; Proto-oncogene homologous sequences in the sea urchin genome. Biosci Rep 1 October 1988; 8 (5): 415–419. doi: https://doi.org/10.1007/BF01121638
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