The problem of regulation of cell division is essentially a problem of understanding regulation of transition from the resting state of a cell to the dividing state and vice versa. In malignancy the ability to revert back to a normal resting state is impaired. A model is presented which attempts to explain the control of the above transitions through control of uptake of essential nutrients by a transport-inhibitory protein. Experimental evidence in favour of the model is given.
Research Article| December 01 1988
Regulation of cell division and malignant transformation
Pushpa M. Bhargava;
Biosci Rep (1988) 8 (6): 519–529.
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Pushpa M. Bhargava, Sushil A. Chandani; Regulation of cell division and malignant transformation. Biosci Rep 1 December 1988; 8 (6): 519–529. doi: https://doi.org/10.1007/BF01117330
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