Blood platelets have the capacity to participate in a number of physiological as well as pathological processes within the circulation. In order to evaluate their cellular reactivity a number of platelet function tests have been developed. The main in vitro function tests are assessment of aggregation and adhesion, secretion, arachidonate metabolism, coagulant activities and the characterization of surface membrane glycoproteins (Day and Rao, 1986). Here we measure alterations of the G-/F-actin equilibrium of platelets. High F-actin values of unstimulated platelets indicate a hyperreactivity of the cell as examined in platelets from diabetics. Determination of the actin filament content in platelets can be considered as a new sensitive function test.
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June 01 1989
Actin filament content in platelets—A sensitive index of cellular reactivity
P. Spangenberg;
P. Spangenberg
1Institute of Pathological Biochemistry, Medical Academy, Erfurt 5010, GDR
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Publisher: Portland Press Ltd
Received:
October 10 1988
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1989 Plenum Publishing Corporation
1989
Biosci Rep (1989) 9 (3): 307–313.
Article history
Received:
October 10 1988
Citation
P. Spangenberg, U. Till; Actin filament content in platelets—A sensitive index of cellular reactivity. Biosci Rep 1 June 1989; 9 (3): 307–313. doi: https://doi.org/10.1007/BF01114683
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