This study was undertaken to investigate the effect of diazepam in the presence and absence of glibenclamide, metformin or their combination on serum levels of glucose, insulin and chromium in rats. Results indicated that diazepam (10 mg/kg i.p.) induced marked hyperglycaemic effects in hyperglycaemic rats. This effect was associated with significant reductions in serum chromium levels and insignificant reduction in serum insulin levels. Diazepam-induced hyperglycaemia was counter-acted by concurrent administration of glibenclamide (5 mg/kg orally), metformin (500 mg/kg orally) or their combination. The effect of diazepam on serum chromium level was counteracted partially by administration of glibenclamide and augmented in the presence of metformin or its combination with glibenclamide. It is concluded that the diazepam-induced hyperglycaemia, as well as the hypoglycaemic effect of glibenclamide, might be related to changes in serum chromium levels.
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June 01 1989
Interaction between diazepam and oral antidiabetic agents on serum glucose, insulin and chromium levels in rats
F. A. A. Al-Ahmed;
F. A. A. Al-Ahmed
1Department of Pharmacology, College of Pharmacy, King Saudi University, P.O. Box 2457, Riyadh-11451, Kingdom of Saudi Arabia
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E. S. M. El-Denshary;
E. S. M. El-Denshary
1Department of Pharmacology, College of Pharmacy, King Saudi University, P.O. Box 2457, Riyadh-11451, Kingdom of Saudi Arabia
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M. Zaki;
M. Zaki
1Department of Pharmacology, College of Pharmacy, King Saudi University, P.O. Box 2457, Riyadh-11451, Kingdom of Saudi Arabia
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H. A. El-Sawaf;
H. A. El-Sawaf
1Department of Pharmacology, College of Pharmacy, King Saudi University, P.O. Box 2457, Riyadh-11451, Kingdom of Saudi Arabia
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A. R. Abu-Jayyab
A. R. Abu-Jayyab
1Department of Pharmacology, College of Pharmacy, King Saudi University, P.O. Box 2457, Riyadh-11451, Kingdom of Saudi Arabia
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Publisher: Portland Press Ltd
Received:
November 07 1988
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1989 Plenum Publishing Corporation
1989
Biosci Rep (1989) 9 (3): 347–350.
Article history
Received:
November 07 1988
Citation
F. A. A. Al-Ahmed, E. S. M. El-Denshary, M. Zaki, H. A. El-Sawaf, A. R. Abu-Jayyab; Interaction between diazepam and oral antidiabetic agents on serum glucose, insulin and chromium levels in rats. Biosci Rep 1 June 1989; 9 (3): 347–350. doi: https://doi.org/10.1007/BF01114687
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