Electrical conductivity across phospholipid bilayers induced by various cytotoxic proteins has been used to analyse the damaging action of such proteins on cells; the protective effect of divalent cations and protons against such attack has also been investigated. The predominant effect of divalent cations and protons is to promote the closed state of membrane pores, i.e. to “gate” protein-induced lesions.
Keywords:
planar bilayers,
phospholipid,
conductivity,
divalent cations,
protons,
cytotoxic proteins,
gating
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© 1989 Plenum Publishing Corporation
1989
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