The interactions involving cells of the nervous system are a complex form of intercellular communication. Biosynthesis of peptide hormones or active neuropeptides is generally through a precursor which provides increased product choices as a function of the processing pathway. Proteolytic processing as well as other molecular modification lead to a wide range of mature products which may vary in different tissues even though they are derived from the same precursor. Also the same neuropeptide may exhibit different bioactivities for different target cells. Finally, by means of collective packaging in secretory organelles, a cell may be able by synergism to further broaden its biologic effects. In these ways, what is seen as added complication in the CNS, may be from the point of view of the cell, a successful attempt to increase its survival ability to adapt and influence its bioenvironment.
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December 01 1989
Functional diversity of bioactive peptides in the nervous system itself: “How the brain may understand”
Michel Chrétien;
Michel Chrétien
1J. A. de Sève Laboratory of Molecular and Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
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Roy A. Sikstrom;
Roy A. Sikstrom
1J. A. de Sève Laboratory of Molecular and Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
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Claude Lazure;
Claude Lazure
1J. A. de Sève Laboratory of Molecular and Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
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Majambu Mbikay;
Majambu Mbikay
1J. A. de Sève Laboratory of Molecular and Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
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Nabil G. Seidah
Nabil G. Seidah
1J. A. de Sève Laboratory of Molecular and Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
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Publisher: Portland Press Ltd
Received:
March 21 1989
Revision Requested:
July 13 1989
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1989 Plenum Publishing Corporation
1989
Biosci Rep (1989) 9 (6): 693–700.
Article history
Received:
March 21 1989
Revision Requested:
July 13 1989
Citation
Michel Chrétien, Roy A. Sikstrom, Claude Lazure, Majambu Mbikay, Nabil G. Seidah; Functional diversity of bioactive peptides in the nervous system itself: “How the brain may understand”. Biosci Rep 1 December 1989; 9 (6): 693–700. doi: https://doi.org/10.1007/BF01114807
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