Replicative senescence may provide a mechanism of tumor suppression and tumor suppressor genes of the extracellular matrix, like lysyl oxidase, may play a role in cellular senescence. To test this hypothesis and determine whether the extracellular matrix may serve as a marker, the steady-state levels of human lysyl oxidase, α-I type III collagen and β-actin transcripts were assessed in various cell lines during in vitro passge. Northern hybridization analysis showed a significant increase in the levels of progeria fibroblast extracellular matrix mRNAs immediately preceding senescence. The levels of these mRNAs were unaffected in age-matched normal fibroblast and fetal fibroblast cell lines.
Research Article| August 01 1997
Lysyl Oxidase, Cellular Senescence and Tumor Suppression
Jeffrey A. Kramer;
Biosci Rep (1997) 17 (4): 409–414.
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Rashmi Sharma, Jeffrey A. Kramer, Stephen A. Krawetz; Lysyl Oxidase, Cellular Senescence and Tumor Suppression. Biosci Rep 1 August 1997; 17 (4): 409–414. doi: https://doi.org/10.1023/A:1027361418200
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