The hybridoma antibody TL5, which precipitates the EGF receptor from the human epidermoid carcinoma cell line A431, has been shown to recognize the blood-group-A carbohydrate structure. This conclusion has been reached from studies of (a) the binding of the antibody to glycoproteins and haemagglutination of erythrocytes with known blood-group-antigen activities and (b) the inhibition of binding of the antibody to a radiolabelled blood-group-A-active glycoprotein by structurally defined oligosaccharides.
Monoclonal antibody reactive with the human epidermal-growth-factor receptor recognizes the blood-group-A antigen
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H. C. Gool, J. Schlessinger, I. Lax, Y. Yarden, T. A. Libermann, T. Feizi; Monoclonal antibody reactive with the human epidermal-growth-factor receptor recognizes the blood-group-A antigen. Biosci Rep 1 November 1983; 3 (11): 1045–1052. doi: https://doi.org/10.1007/BF01121031
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