The effect of bradykinin on prostaglandin E2 formation in cells from human trabecular bone has been studied. The cells responded to parathyroid hormone with enhanced cyclic AMP formation and were growing as cuboidal-shaped, osteoblast-like cells. In these isolated human osteoblast-like cells, bradykinin (1 μmol/l) caused a rapid (5 min) stimulation of prostaglandin E2 formation. This finding indicates that human osteoblasts are equipped with receptors for bradykinin linked to an increase in prostaglandin formation.
Bradykinin stimulates prostaglandin E2 formation in isolated human osteoblast-like cells
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Östen Ljunggren, Jan Rosenquist, Maria Ransjö, Ulf H. Lerner; Bradykinin stimulates prostaglandin E2 formation in isolated human osteoblast-like cells. Biosci Rep 1 February 1990; 10 (1): 121–126. doi: https://doi.org/10.1007/BF01116860
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