The effect of the antiemetic chlorpromazine on bleomycin- and epirubicin cytotoxicity was tested in vitro. Chlorpromazine (0.1 or 0.01 mg/l) enhanced epirubicin-induced toxicity to cultured Chinese fibroblasts whereas 0.01 mg/l chlorpromazine inhibited the cytotoxicity of bleomycin. The results encourage further studies on the effects of commonly used antiemetics on the cytotoxicity and antitumoral effects of anticancer chemotherapeutics.
Rapid Communication| April 01 1990
Different effects of chlorpromazine on bleomycin-and epirubicin induced cytotoxicity
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Kjell Grankvist, Per Bergström, Roger Henriksson; Different effects of chlorpromazine on bleomycin-and epirubicin induced cytotoxicity. Biosci Rep 1 April 1990; 10 (2): 173–177. doi: https://doi.org/10.1007/BF01116576
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