The amino acid composition of proteins from liver microsomes has been studied in rats and in human subjects with normal liver, with obstructive jaundice or liver cirrhosis. The pattern of the amino acid composition of microsomes appeared to be species-specific. Phenylalanine, threonine, serine, proline, histidine and [aspartic acid plus asparagine] were increased, while alanine, tyrosine, glycine and arginine were decreased in the human compared to the rat microsomes. In patients with obstructive jaundice of short duration (less than two months) only a slight decrease in leucine and phenylalanine could be noticed, while in the case of liver cirrhosis amino acid composition was markedly changed.
Research Article| April 01 1995
Amino acid composition of rat and human liver microsomes in normal and pathological conditions
Biosci Rep (1995) 15 (2): 111–116.
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Gheorghe Benga, William Ferdinand; Amino acid composition of rat and human liver microsomes in normal and pathological conditions. Biosci Rep 1 April 1995; 15 (2): 111–116. doi: https://doi.org/10.1007/BF01200145
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