“In general there is no set of observations conceivable which can give enough information about the past of a system to give complete information as to its future”: Norbert Wiener. “Think simplicity; then discard it”: Alfred North Whitehead

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Author notes

The Nobel Lecture given on December 8, 1994 by Professor Martin Rodbell and published in Les Prix Nobel 1994, printed by Norstedts Tryckeri, republished here with the permission of the Nobel Foundation, copyright holder.