Ca2+-uptake into intracellular stores is mediated by the sarco/endoplasmic reticulum Ca2+ATPases (SERCAs). This review deals first with the gene structural and the characterization of the tissue-specific SERCA2 transcript processing. Secondly, the two different protein isoforms and their regulation are described. Finally, this review ends with a discussion on the possible physiological role of the SERCA2 isoform diversity.

Abbreviations SERCA, sarco/endoplasmic reticulum Ca-ATPase; PLB, phospholamban; EP, phosphoenzyme intermediate; Vmax', maximal velocity;

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