We propose an overview of the mechanism of Ca2+ transport through the sarcoplasmic reticulum membrane via the Ca2+-ATPase. We describe cytoplasmic calcium binding, calcium occlusion in the membrane and lumenal calcium dissociation. A channel-like structure is discussed and related to structural data on the membranous domain of the Ca2+-ATPase.

Abbreviations SR, Sarcoplasmic Reticulum; AMPPNP, adenylyl-imidodiphosphate; AMPPCP, adenylyl (β,γ-methylene)-diphosphonate; FITC, fluorescein 5′-isothiocyanate; NBD, 4-nitrobenzo-2-oxa-1,3-diazole; DCCD, dicyclohexylcarbodiimide;

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