Evidence is available showing that the coupling efficiency of the proton pump in cytochrome c oxidase of mitochondria can under certain conditions decrease significantly below the maximum attainable value. The view is developed that slips in the proton pump of cytochrome c oxidase represent an intrinsic switch mechanism which regulates the relative contribution of energy transfer and respiratory protection against oxygen toxicity by the oxidase.
Review Article| February 01 1997
A Possible Role of Slips in Cytochrome C Oxidase in the Antioxygen Defense System of the Cell
Biosci Rep (1997) 17 (1): 23–31.
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S. Papa, F. Guerrieri, N. Capitanio; A Possible Role of Slips in Cytochrome C Oxidase in the Antioxygen Defense System of the Cell. Biosci Rep 1 February 1997; 17 (1): 23–31. doi: https://doi.org/10.1023/A:1027331116866
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