The effect of a short-term oral administration of potassium cyanide (KCN) (200 ppm in diet) with or without sodium nitrite (NaNO2) pretreatment on rat brain microsomal Ca2± ATPase was investigated. The specific activity value of the enzyme significantly decreased (p<0.05) by 50% compared with control and by 63% for KCN-treated rats compared with KCN-treated rats pretreated with NaNO2. There was no significant difference at the h=0.05 level between the values obtained for the control and KCN-treated rats pretreated with NaNO2. These results show both that feeding lowers brain microsomal Ca2+-ATPase activity and that NaNO2 has a protective role (antidote function) in that respect.
Sodium Nitrite Alone Protects the Brain Microsomal Ca2+-ATPase Against Potassium Cyanide-induced Neurotoxicity In Rats
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O. O. Odunuga, G. A. Adenuga; Sodium Nitrite Alone Protects the Brain Microsomal Ca2+-ATPase Against Potassium Cyanide-induced Neurotoxicity In Rats. Biosci Rep 1 December 1997; 17 (6): 543–546. doi: https://doi.org/10.1023/A:1027312324077
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